Usage Note
Desgraciadamente is a sentence adverb used to express regret about a situation, equivalent to English 'unfortunately' or 'sadly.' It is interchangeable with lamentablemente. The root noun is desgracia ('misfortune'), and the related adjective desgraciado can mean 'unfortunate' or, more harshly, 'wretched/despicable' depending on context.
Examples
"Desgraciadamente, no pudimos asistir a la boda."
Natural Translation
Unfortunately, we could not attend the wedding.

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