Usage Note
Bolso is the standard word for a handbag in Spain; in much of Latin America cartera or bolsa is preferred instead. Bolsillo (pocket) is a diminutive of bolso but is not interchangeable with it. A bolso de mano is a clutch bag, while a mochila is a backpack.
Examples
"Dejó el bolso sobre la silla del restaurante."
Natural Translation
She left her handbag on the restaurant chair.

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