Usage Note
Detergente is masculine despite ending in -e, so it is el detergente. It covers both laundry detergent and dishwashing liquid; to be specific, Spanish speakers say detergente para la ropa or detergente lavavajillas. The plural detergentes follows the regular pattern.
Examples
"Se me acabó el detergente para la ropa."
Natural Translation
I ran out of laundry detergent.

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