Usage Note
En covers location ('in', 'at', 'on') and can also express manner or means (en coche 'by car', en serio 'seriously'). It is the standard preposition for languages and vehicles used as transport (hablar en español, ir en tren), which can surprise learners used to English preposition choices. Unlike a, en focuses on position rather than direction of movement.
Examples
"Vivo en Madrid."
Natural Translation
I live in Madrid.

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